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Assay-kits

SensoLyte® 520 MMP Substrate Sampler Kit Fluorimetric - 1 kit

$806.00
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  • Cat.Number : AS-71170
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    In stock
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Matrix metalloproteinases (MMPs) belong to a family of secreted or membrane-associated proteins capable of digesting extracellular matrix components. They are involved in diseases such as cancer, arthritis, asthma, angiogenesis, alopecia and metastasis. They are also identified as drug-screening targets. SensoLyte® 520 MMP Substrate Sampler Kit contains a series of FRET peptide substrates for use as fluorogenic indicators to assay MMP protease activities. It provides the best solution for identifying a suitable fluorogenic substrate for a particular MMP assay. All the MMP substrates in the kit are also available in bulk packages.

Specifications

Packaging
Kits components
  • Component A: 16 different MMP substrates. Ex/Em=490 nm/520 nm upon cleavage: 100 µM, 150 µL each Component B: 5-FAM-Pro-Leu-OH, fluorescence reference standard Ex/Em=490 nm/520 nm: 1 mM, 10 µL Component C: APMA, 4-aminophenylmercuric acetate: 1 M, 100 µL Component D: Assay buffer: 50 mL Component E: Stop solution: 30 mL
Properties
Absorbance (nm)
  • 490
Emission (nm)
  • 520
Storage & stability
Storage Conditions
  • Store all components at –20°C. Keep Components A and B from light.
Activity
Application
Biomarker Target
Detection Method
Research Area
Sub-category Research Area
Usage
  • Research use

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Citations

Thymosin beta 4 Gene Silencing Decreases Stemness and Invasiveness in Glioblastoma

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  • H-G. Wirsching
  • et al

Dopamine-dependent ectodomain shedding and release of epidermal growth factor in developing striatum: target-derived neurotrophic signaling (Part 2)

J Neurochem . 2011 May 25 ; 118(1) 57 | DOI : 10.1111/j.1471-4159.2011.07295.x

  • Y. Iwakura
  • et al

Activated Abl kinase inhibits oncogenic transforming growth factor-β signaling and tumorigenesis in mammary tumors

FASEB J . 2009 Aug 18 ; 23(12) 4231 | DOI : 10.1096/fj.09-138412

  • T.M. Allington
  • et al

Systematic identification of substrates for profiling of secreted proteases from Aspergillus species

J Microbiol Methds . 2007 May 29 ; 71(2) 93 | DOI : 10.1016/j.mimet.2007.05.010

  • R. Schaal
  • et al

Degradation of the Alzheimer Disease amyloid β-peptide by metal-dependent upregulation of metalloprotease activity

J Biol Chem . 2006 Apr 28 ; 281(26) 17670 | DOI : 10.1074/jbc.M602487200

  • A.R. White
  • et al